The Zinc Distribution Characteristics in Rats after Exposing to Nano-sized Zinc Oxide
Date Issued
2008
Date
2008
Author(s)
Chen, Li-An
Abstract
Nano-sized zinc oxide shows advantages in many ways and has been applied in chemical engineering, optoelectronics, biomedicine and so forth. However, some toxicological studies showed that nano particles may cause adverse health effect such as inflammation, thrombosis, etc. In addition, nano particles could be redistributed to or accumulate in the secondary organs or tissues from the deposition site by circulation. The objective of this pilot study is to explore the zinc distribution characteristics in rats after exposing to nano-sized zinc oxide.his study included two parts: exposure effects and kinetics. In the first part, 8-week-old healthy male Sprague-Dawley (SD) rats were exposed to 30 nm and 250 nm zinc oxide for 5 and 10 hrs, respectively, in a whole body exposure chamber and then sacrificed at 24 hours post-exposure. In the second part, batches of SD rats were exposed to 30 nm zinc oxide for 10 hours. As the non-exposed control batch were sacrificed without nano-sized zinc oxide exposure, the other exposed batches were sacrificed at 2, 4, 8, 16, 24 hours post-exposure. Samples of brain, lung, heart, liver, kidney, plasma, serum and whole blood were collected and digested for zinc analysis by inductively coupled plasma-mass spectrometer (ICP-MS).n the first part, there were significant dose-response relationships for zinc concentration in liver and plasma samples, while such relationships were weak in lung and kidney samples. In contrast, zinc concentrations in brain and serum samples were almost independent of the exposure conditions. In the second part, the zinc levels in liver at 2 hours post-exposure, in heart at 4 hours post-exposure and in whole blood at 8 hours post-exposure rose up slightly and then descended to the ground level, whereas the zinc level in other organs had no obvious fluctuation during the 24 hours post-exposure period.he results of this study provided some information regarding the zinc distribution pattern in rats after exposing to nano-sized zinc oxide particles. Combined with physiologically based pharmacokinetic model (PBPK model), the continued research following this pilot study can be used to explore the redistribution profile of zinc in animal model after exposing to nano-sized zinc oxide and perform the health risk assessment for nano-sized zinc oxide.
Subjects
zinc oxide
nano-sized
distribution
animal model
SDGs
Type
thesis
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