Role of Streptococcus mutans surface proteins in vegetation formation during infective endocarditis
Date Issued
2006
Date
2006
Author(s)
Zheng, Quan-Hau
DOI
zh-TW
Abstract
Infective endocarditis (IE) is an infectious disease of the cardiovascular system, and carries a high recurrence and mortality rate. Streptococcus mutans, a member of viridans streptococci, is one of the major opportunistic pathogens for causing IE. The interactions of plasma components with bacterial surface proteins play important roles in vegetation formation. Using experimental infective endocarditis rat model, we investigated the role of bacterial surface proteins in vegetation formation in vivo. Latex beads coated with cell-wall assaciated proteins of S. mutans could induce vegetaion formation directly; in contrast latex beads coated with bovine serum albumin could not. The beads could be detected in vegetation by transmisson electron microscope and immunofluorescent staining. Among bacterial surface proteins, fibrinogen and fibronetin binding proteins are important for bacteria escaping from leukocyte phagocytosis and attachment to heart valve. Fngb, one of S. mutans fibrinogen (fibronectin) binding proteins, was also studied in vivo. When compared with wild type strain, the fngb mutant caused milder infective endocarditis. Vegetation in smaller size and less number of bacteria colonized was isolated from fngb null mutant induced vegetation. These results demonstrated bacterial surface protein play an important role in vegetation formation in vivo.
Subjects
心內膜炎
infective endocarditis
SDGs
Type
other
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