Carteraol E, a potent polyhydroxyl ichthyotoxin from the dinoflagellate Amphidinium carterae
Journal
Tetrahedron Letters
Journal Volume
50
Journal Issue
21
Pages
2512-2515
Date Issued
2009
Author(s)
Abstract
Carteraol E (1), C74H126O24, a polyhydroxyl ichthyotoxin, was isolated from the lab-cultured marine dinoflagellate Amphidinium carterae. Carteraol E possessed three tetrahydropyrans, and 19 hydroxyl groups on a C69-linear aliphatic chain with a ketone moiety, an exo-methylene, and three methyl branches. The structure was elucidated by extensive analyses of 2D NMR spectra. Cateraol E exhibited potent ichthyotoxicity with LD50 value of 0.28 μM, and antifungal activity against Aspergillus niger. © 2009 Elsevier Ltd. All rights reserved.
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