Urinary neutrophil gelatinase-associated lipocalin is a potential biomarker for renal damage in patients with systemic lupus erythematosus
Journal
Journal of Biomedicine and Biotechnology
Journal Volume
2012
Date Issued
2012
Author(s)
Abstract
Neutrophil gelatinase-associated lipocalin (NGAL) has been demonstrated to be a novel biomarker in acute and chronic kidney disease. We hypothesized that 24-hour urinary NGAL excretion may be a predictor for renal damage in patients with systemic lupus erythematosus (SLE). Thirty-four SLE patients with renal involvement (SLE-renal group), 8 SLE patients without renal involvement (SLE-nonrenal group), 14 patients with non-SLE autoimmune diseases (disease control or DC group), and 12 healthy volunteers (normal control or NC group) were compared for 24-hour urinary excretion of NGAL and different cytokines. We found that the 24-hour urinary NGAL excretion in the SLE-renal group was higher than that in the SLE-non-renal, DC, and NC groups. However, the excretion of interleukin-10, transforming growth factor- 1, and tumor necrosis factor- was not different between the SLE-renal and SLE-non-renal groups. Furthermore, NGAL excretion in the SLE-renal group was correlated with serum creatinine levels and creatinine clearance, but not with the SLE Disease Activity Index score. Multivariate logistic regression analysis and receiver operating characteristic curve analysis revealed that 24-hour urinary NGAL excretion is a potential biomarker for renal damage in SLE patients, with higher sensitivity and specificity than anti-dsDNA antibody titers. Copyright 2012 Chun-Chen Yang et al.
SDGs
Other Subjects
creatinine; cytokine; interleukin 10; neutrophil gelatinase associated lipocalin; transforming growth factor beta1; tumor necrosis factor alpha; acute phase protein; biological marker; IL10 protein, human; interleukin 10; LCN2 protein, human; lipocalin; oncoprotein; transforming growth factor beta1; tumor necrosis factor alpha; adult; article; controlled study; creatinine blood level; creatinine clearance; disease activity; female; human; lupus erythematosus nephritis; major clinical study; male; named inventories, questionnaires and rating scales; receiver operating characteristic; systemic lupus erythematosus; Systemic Lupus Erythematosus Disease Activity Index; urinary excretion; middle aged; nephritis; proteinuria; statistical model; systemic lupus erythematosus; urine; Acute-Phase Proteins; Adult; Biological Markers; Female; Humans; Interleukin-10; Lipocalins; Logistic Models; Lupus Erythematosus, Systemic; Male; Middle Aged; Nephritis; Proteinuria; Proto-Oncogene Proteins; ROC Curve; Transforming Growth Factor beta1; Tumor Necrosis Factor-alpha
Type
journal article