Association of Single-Nucleotide Polymorphism 3 and C.553g > T of Apoa5 with Hypertriglyceridemia after Treatment with Highly Active Antiretroviral Therapy Containing Protease Inhibitors in Hiv-Infected Individuals in Taiwan
Resource
CLINICAL INFECTIOUS DISEASES v.48 n.6 pp.832-835
Journal
CLINICAL INFECTIOUS DISEASES
Journal Volume
v.48
Journal Issue
n.6
Pages
832-835
Date Issued
2009
Date
2009
Author(s)
CHANG, SUI-YUAN
KO, WEI-SHIN
KAO, JAU-TSUEN
LEE, CHUN-NAN
SUN, HSIN-YUN
CHEN, MAO-YUAN
HSIEH, SZU-MIN
SHENG, WANG-HUEI
CHANG, SHU-FANG
LIU, WEN-CHUN
WU, CHENG-HSIN
CHANG, SHAN-CHWEN
KAO, CHUAN-LIANG
HUNG, CHIEN-CHING
Abstract
We investigated the relationship between hypertriglyceridemia and the single-nucleotide polymorphisms (SNPs) on APOA5 in human immunodeficiency virus (HIV)- infected patients receiving highly active antiretroviral therapy (HAART) in Taiwan. Receipt of protease inhibitor- based HAART, high baseline triglyceride levels, and carriage of APOA5 SNP3 or c.553G>T variants or APOA5 SNP1T/SNP2G/SNP 3C/c.553T haplotype were statistically significantly associated with development of extreme hypertriglyceridemia( triglyceride level, >500 mg/dL)
SDGs