Consecutive dynamic resolutions of phosphine oxides
Journal
Chemical Science
Journal Volume
5
Journal Issue
4
Pages
1322-1327
Date Issued
2014
Author(s)
Kortmann, Felix A.
Chang, Mu-Chieh
Otten, Edwin
Couzijn, Erik P. A.
Lutz, Martin
Minnaard, Adriaan J.
Abstract
A crystallization-induced asymmetric transformation (CIAT) involving a radical-mediated racemization provides access to enantiopure secondary phosphine oxides. A consecutive CIAT is used to prepare enantio- and diastereo-pure tert-butyl(hydroxyalkyl)phenylphosphine oxides. © 2014 The Royal Society of Chemistry.
Type
journal article