Tumor-Derived C-C Motif Ligand 2 Induces the Recruitment and Polarization of Tumor-Associated Macrophages and Increases the Metastatic Potential of Bladder Cancer Cells in the Postirradiated Microenvironment
Journal
International journal of radiation oncology, biology, physics
Journal Volume
114
Journal Issue
2
Pages
321
Date Issued
2022-10
Author(s)
Wang, Chung-Chieh
Chung, Shiu-Dong
Abstract
Radiation therapy (RT) is mainly used for bladder preservation in patients with muscle-invasive bladder cancer. The response of urothelial tumors to RT remains unsatisfactory. We investigated the interaction of RT and tumor-associated macrophages (TAMs) in the context of bladder cancer radioresistance.
Subjects
PANCREATIC-CANCER; THERAPY; CCL2; RADIOTHERAPY; PHENOTYPE; RADIATION; VASCULOGENESIS; ANGIOGENESIS; IRRADIATION; INHIBITION
SDGs
Publisher
ELSEVIER SCIENCE INC
Type
journal article