The prevalence and outcome of short-acting β2-agonists overuse in asthma patients in Taiwan
Journal
NPJ primary care respiratory medicine
Journal Volume
31
Journal Issue
1
Date Issued
2021
Author(s)
Abstract
This study aims to investigate the prevalence of short-acting β2-agonist (SABA) overuse in asthma and the associated risk of acute exacerbation and mortality in Taiwan. We used the Taiwanese pay-for-performance asthma program database, which included patients aged between 12 and 100 years who were enrolled in the program between 2001 and 2015. Among a total of 218,039 patients, 34,641 (15.9%) patients are classified as SABA over-users. Compared with patients who did not receive inhaled corticosteroids (ICS) and collected ≤2 canisters, SABA over-users had a higher risk of severe exacerbations. SABA over-users had a higher risk of all-cause mortality compared with patients who did not receive ICS and collected ≤2 canisters. The overall prevalence of SABA overuse in Taiwan is 15.9%, and this is even higher in concomitant ICS users. In addition, the overuse of SABA is associated with an increased risk of severe exacerbation and death.
SDGs
Other Subjects
beta 2 adrenergic receptor stimulating agent; beta adrenergic receptor stimulating agent; bronchodilating agent; corticosteroid; long acting drug; muscarinic receptor blocking agent; short acting drug; xanthine; antiasthmatic agent; corticosteroid; adolescent; adult; aged; all cause mortality; Article; asthma; child; cohort analysis; combination drug therapy; controlled study; corticosteroid therapy; disease exacerbation; drug megadose; female; human; low drug dose; major clinical study; male; medication overuse; monotherapy; prevalence; systemic therapy; Taiwan; asthma; inhalational drug administration; middle aged; prevalence; reimbursement; very elderly; young adult; Administration, Inhalation; Adolescent; Adrenal Cortex Hormones; Adult; Aged; Aged, 80 and over; Anti-Asthmatic Agents; Asthma; Child; Humans; Middle Aged; Prevalence; Reimbursement, Incentive; Taiwan; Young Adult
Type
journal article