Preparation of fibril nuclei of beta-amyloid peptides in reverse micelles
Journal
Chemical Communications
Journal Volume
54
Journal Issue
74
Pages
10459-10462
Date Issued
2018
Author(s)
Abstract
We report the preparation of protofibrils from oligomeric Aβ40 aggregates, which have been incubated under spatially constrained conditions. The molecular structure of the resultant protofibrils is highly homogeneous, suggesting that the phenomenon of structural polymorphism commonly observed in Aβ40 fibrils may be largely due to multiple nucleation events.
SDGs
Type
journal article