行政院國家科學委員會補助專題研究計畫成果報告:FE65基因多型性變異與老年性阿滋海默症相關性之本土研究
Date Issued
2002
Date
2002
Author(s)
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DOI
902314B002264
Abstract
The FE65 protein binds to the intracellular domain of the amyloid precursor protein (APP), and
may regulate the metabolism of Aβ. A genetic polymorphism in intro 13 of the FE65 gene has
been reported to be associated with the sporadic late-onset Alzheimer’s disease (AD) recently. This
is a similar investigation in Taiwan. We collect 66 AD patients, and 78 control subjects nearly
matched with age and education level. Most of them have the same “11” genotype, and only one
“12” genotype in the control group. In conclusion, there is no association between the FE65
polymorphism and sporadic late-onset Alzheimer’s disease.
Subjects
polymorphism
Alzheimer’s disease
Publisher
臺北市：國立臺灣大學醫學院神經科
Type
journal article
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