Promoter polymorphisms of tumor necrosis factor-α are associated with risk of gastric mucosa-associated lymphoid tissue lymphoma
Journal
International Journal of Cancer
Journal Volume
110
Journal Issue
5
Pages
695-700
Date Issued
2004
Author(s)
Chen L.-T.
Huang S.-P.
Lin J.-T.
Abstract
Genes involved in regulating antimicrobial immunity and inflammation may modulate the risk of Helicobacter pylori-associated diseases. IL-1 and TNF-α are major cytokines detected in H. pylori-infected tissues. We aimed to determine the role of gene polymorphisms for these cytokines and their receptors in 2 distinct H. pylori-related gastric malignancies, adenocarcinoma (GAC) and maltoma. Genotyping for IL-1β (-31 C/T, -511 C/T), TNF-α (-238 G/A, -308 G/A, -857 C/T, -863 C/A, -1031 T/C), TNFRI (-383 A/C) and TNFR2 (196 G/T) was undertaken for 70 patients with maltoma and 204 patients with noncardia GAC and compared to 210 unrelated healthy controls. Genotype frequencies showed no differences among patients with GAC or maltoma and controls for IL-1β, TNFR1 or TNFR2. The TNF-α-857 T variant was significantly underrepresented in maltoma compared to controls (6.4% vs. 14.3%, p = 0.018), conferring a 3-fold decrease in risk (OR = 0.33, 95% CI 0.15-0.75). Comparison of allele frequencies between GAC and controls failed to show any statistical significance for TNF-α polymorphisms. We concluded that TNF-α -857 T itself or a neighboring gene may modify the risk of maltoma. The differences in genetic background as well as divergent clinicopathologic features between GAC and maltoma support the notion that fundamental mechanistic differences exist in these 2 well-defined H. pylori-related malignancies. ? 2004 Wiley-Liss, Inc.
SDGs
Other Subjects
cytokine; interleukin 1beta; tumor necrosis factor alpha; adenocarcinoma; adult; aged; allele; article; cancer patient; cancer risk; controlled study; female; gastric mucosa associated lymphoid tissue lymphoma; gene frequency; genetic association; genetic polymorphism; genetic risk; genetic susceptibility; genetic variability; genotype; Helicobacter pylori; histopathology; human; major clinical study; male; microbial immunity; mucosa associated lymphoid tissue lymphoma; priority journal; promoter region; stomach mucosa; Adenocarcinoma; Aged; Alleles; DNA Primers; Female; Gastric Mucosa; Gene Frequency; Genotype; Helicobacter pylori; Humans; Interleukin-1; Lymphoid Tissue; Lymphoma; Lymphoma, Mucosa-Associated Lymphoid Tissue; Male; Middle Aged; Polymorphism, Genetic; Risk; Stomach Neoplasms; Tumor Necrosis Factor-alpha
Type
journal article