Application of controllable gene expression system in hair growth
Date Issued
2009
Date
2009
Author(s)
Jan, Hau-Ming
Abstract
Gene transfer to hair follicles is a potential technology to treat skin disease. Non-viral transfection is considered a difficult method to deliver genes into hair follicles in vivo because of the extremely low permeability of skin. We utilized polyethylenimine (PEI) to transfect the human telomerase reverse transcriptase (hTERT) in hair follicle cells in normal and wounding rat skin tissues. We found that expression of hTERT in normal skin tissue could increase the number of proliferating stem cells in hair follicles. On the other hand, expression of hTERT in wounding skin tissue can promote hair follicle de novo formation. These studies might not only reveal an innovative method for gene transfer, but also provide a practical solution for skin disease therapy.
Subjects
PEI (polyethylenimine)gene transfer
hTERT (human telomerase reverse transcriptase)
hair follicle stem cell
hair growth
SDGs
Type
thesis
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