第二型巨噬細胞發炎蛋白在動物模式呼吸器引發肺損傷角色之探討
Other Title
The Role of Macrophage Inflammatory Protein-2 in the Development of Ventilator-Induced Lung
Injury in a Rat Model
Injury in a Rat Model
Date Issued
2005
Date
2005
Author(s)
鄭之勛
DOI
932314B002223
Abstract
Rationale: Mechanical ventilation may be responsible not only for worsening the underlying lung injury, but may also lead to
the development of new lung injury, i.e., ventilator-induced lung injury (VILI) as well as systemic inflammatory response
syndrome and multiple organ failure. Objectives: To study the role of macrophage inflammatory protein-2 (MIP-2), a
functional equivalent of interleukin-8 of the chemokine group, in the pathogenesis of VILI, and to investigate the
renin-angiotensin system in the involvement of VILI and possible of regulation of MIP-2 expression in VILI. Methods:
Sprague-Dawley rats were mechanically ventilated for four hours with either low (7 ml/kg) or high (40 ml/kg) tidal volumes.
Histologic studies, measurements of the myeloperoxidase activity and nuclear factor-κ B activity, quantification of the mRNA
as well as protein levels of MIP-2 in the lungs, and assessment of the expression after treatment with captopril, and
angiotensin-converting enzyme inhibitor, were performed. Main Results: In the high-volume group, lung tissue neutrophil
infiltration, activity of nuclear factor -κ B, tumor-necrosis factor-α , and macrophage inflammatory protein-2 were significantly
increased, and survival was significantly reduced. Treatment with captopril attenuated the lung neutrophil infiltration,
tumor-necrosis factor-α , macrophage inflammatory protein-2, and nuclear factor-κ B activity in the high-volume group, with
significant survival benefit. Conclusions: Injurious mechanical ventilation is associated with significantly increased expression
of macrophage inflammatory protein-2 in rat lungs, with prominently increased neutrophil infiltration. Treatment with
angiotensin-converting enzyme inhibitor can attenuate MIP-2 expression and ventilator-induced lung injury in the animal
model.
Subjects
Ventilator-induced lung injury
macrophage-inflammatory protein-2
angiotensin-converting enzyme
Publisher
臺北市：國立臺灣大學醫學院內科
Type
report
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