雌激素代謝基因多型性與乳癌致癌感受性及療效的關係
Date Issued
2003-04-30
Date
2003-04-30
Author(s)
黃俊升
DOI
913112B002025
Abstract
Both epidemiological and cell biology studies have documented the contribution of
estrogen to the development of breast cancer. It is, therefore, important to examine the
association between the key variables in estrogen homeostasis (i.e., the synthesis and
catabolism of estrogen, and the sensitivity of tissue to estrogen operated via estrogen
receptor) and the risk of developing breast cancer. A complete understanding of the
etiological role of estrogen in breast carcinogenesis will require studies that evaluate both
the genes participating in estrogen metabolism and the extent to which estrogen exposure
modifies the associations of these genes with breast cancer risk. The treatments of breast
cancer include local control and systemic treatments. The latter includes chemotherapy and
hormonal therapy. Hormonal therapy is indicated in cancers with the presence of estrogen
receptor or progesterone receptor. Hormonal therapy for breast cancer is aimed at
antagonizing the hormone receptor or at lowering the level of hormone. This proposal is
composed of two parts. The little estrogen produced in postmenopausal women comes
predominantly from aromatization of androgens. Aromatase inhibitor can inhibit the
conversion. The first part of the study, a prospective case-control study, is aiming at
determining whether estrogen level and genotypic polymorphisms of estrogen receptor and
estrogen-metabolizing enzymes are associated with individual susceptibility to breast
cancer. So far we have collected DNA and plasma bank of 300 cases. The second part of
the study, based on our previous clinical data and DNA bank of 500 primary invasive breast
cancers operated at the National Taiwan University Hospital from 1989 to 2000, will
determine whether genotypic polymorphisms of estrogen receptor and aromatase are
related to response to anti-estrogen treatment in breast cancer patients. Genotyping of these
specimens has been completed and survival analysis will be done soon.
Subjects
breast cancer
estrogen metabolism
estrogen receptor
genetic polymorphism
cancer susceptibility
treatment
prognosis
SDGs
Publisher
臺北市：國立臺灣大學醫學院外科
Type
report
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