Red mold dioscorea: A potentially safe traditional function food for the treatment of hyperlipidemia
Journal
Food Chemistry
Journal Volume
134
Journal Issue
2
Pages
1074-1080
Date Issued
2012
Author(s)
Abstract
A study was undertaken to evaluate whether the interaction between Monascus-fermented products and lovastatin contributes to increased risk of rhabdomyolysis. Rhabdomyolysis is a potentially dangerous side effect of statin drugs. In this study with hyperlipidemic hamsters fed lovastatin only, lovastatin with 1-fold red mold dioscorea (RMD), and lovastatin, the functional components of red mold fermented products, HMG-CoA reductase inhibitors, did not exacerbate pre-existing diseases, and actually helped in improving existing disease conditions, respectively, as compared with the control. Administration of RMD, alone or in combination with lovastatin did not cause significant rhabdomyolysis as assessed by measuring the levels of creatinine phosphokinase. Further, we did not find any study that clearly implicates the involvement of RMD, which have long been considered a food product, in liver and kidney toxicity. RMD alone or in combination with lovastatin, does not increase the risk of rhabdomyolysis, even when administered at a high dosage (including HMG-CoA reductase inhibitors >75 mg/day/adult). ? 2012 Elsevier Ltd. All rights reserved.
Subjects
Hyperlipidemia; Lovastatin; Monascus purpureus; Red mold dioscorea; Rhabdomyolysis
SDGs
Other Subjects
Hyperlipidemia; Lovastatin; Monascus purpureus; Red mold dioscorea; Rhabdomyolysis; Disease control; Molds; creatine kinase MM; hydroxymethylglutaryl coenzyme A reductase inhibitor; mevinolin; animal experiment; animal model; animal tissue; article; controlled study; diet supplementation; disease exacerbation; fermented product; food drug interaction; hyperlipidemia; liver toxicity; male; nephrotoxicity; nonhuman; red mold dioscorea; rhabdomyolysis; risk assessment; risk reduction; toxicity testing; yam; Animals; Cholesterol; Combined Modality Therapy; Cricetinae; Dioscorea; Fermentation; Functional Food; Humans; Hyperlipidemias; Hypolipidemic Agents; Liver; Lovastatin; Male; Mesocricetus; Monascus; Rhabdomyolysis; Triglycerides; Cricetinae; Dioscorea; Monascus; Monascus purpureus
Type
journal article