Gastroesophageal reflux disease and sleep quality in a Chinese population
Journal
Journal of the Formosan Medical Association
Journal Volume
108
Journal Issue
1
Pages
53-60
Date Issued
2009
Author(s)
Lin J.-T.
Chang K.-Y.
Abstract
Background/Purpose: Although evidence suggests that gastroesophageal reflux disease (GERD) may interrupt sleep, the effects of symptomatic and endoscopically diagnosed GERD remain elusive because the patient population is heterogeneous. Accordingly, we designed a cross-sectional study to assess their association. Methods: Consecutive participants in a routine health examination were enrolled. Definition and severity of erosive esophagitis were assessed using the Los Angeles classification system. Demographic data, reflux symptoms, sleep quality and duration, exercise amount, alcohol consumption, and smoking habits were recorded. Factors affecting sleep quality and sleep duration were revealed by a polytomous logistic regression analysis. Results: A total of 3663 participants were recruited. Subjects with reflux symptoms, female gender, higher body mass index, and regular use of hypnotics had poorer sleep quality. Exercise was associated with better sleep quality. Either symptomatically or endoscopically, GERD did not disturb sleep duration. Among the 3158 asymptomatic patients, those with erosive esophagitis were more likely to have poor sleep quality. The risk increased with the severity of erosive changes (p = 0.03). Conclusion: The present study highlights the adverse effect of gastroesophageal reflux on sleep, even in the absence of reflux symptoms. This finding has therapeutic implications in patients with silent erosive disease, and future trials are warranted. ?2009 Elsevier & Formosan Medical Association.
SDGs
Other Subjects
alcohol; hypnotic agent; adult; alcohol consumption; article; body mass; Chinese; controlled study; demography; disease classification; disease severity; exercise; female; gastroesophageal reflux; human; major clinical study; male; medical examination; population research; reflux esophagitis; sex difference; sleep disorder; sleep time; smoking habit; symptom
Publisher
Scientific Communications International Ltd
Type
journal article