Mpp7 controls regioselective Knoevenagel condensation during the biosynthesis of Monascus azaphilone pigments
Journal
Tetrahedron Letters
Journal Volume
55
Journal Issue
9
Pages
1640-1643
Date Issued
2014
Author(s)
Abstract
Targeted inactivation of the mpp7 gene in the Monascus azaphilone pigment (MAzP) biosynthetic gene cluster resulted in the accumulation of monasfluol A (7) and B (8), of which the latter was a novel compound, and the abolition of the main MAzPs. It is thus proposed that 7 and 8 are the products of non-enzymatic Knoevenagel condensation followed by a reduction and that Mpp7 assists in regioselective Knoevenagel aldol condensation during MAzP biosynthesis. © 2014 Elsevier Ltd. All rights reserved.
Type
journal article