Epithelial Notch signaling regulates lung alveolar morphogenesis and airway epithelial integrity
Journal
Proceedings of the National Academy of Sciences of the United States of America
Journal Volume
113
Journal Issue
29
Pages
8242-8247
Date Issued
2016
Author(s)
Matsuoka C.
Sato A.
Sato S.
Hasegawa K.
Chen H.-K.
Mori M.
Cardoso W.V.
Morimoto M.
Abstract
Significance Formation of the gas-exchange region of the lung occurs largely postnatally through a process called alveologenesis. Alveolar abnormalities are a hallmark of neonatal and adult chronic lung diseases. Here we report that disruption of Notch signaling in mice, particularly by Notch2, results in abnormal enlargement of the alveolar spaces reminiscent of that seen in chronic lung diseases. We provide evidence that Notch is crucial to mediate cross-talk between different cell layers, including signals such as PDGF for formation of the alveoli and maintenance of the integrity of the conducting airways.
SDGs
Type
journal article