Review of microfluidic cell culture devices for the control of gaseous microenvironments in vitro
Journal
Journal of Micromechanics and Microengineering
Journal Volume
28
Journal Issue
4
Date Issued
2018
Author(s)
Abstract
Gaseous microenvironments play important roles in various biological activities in vivo. However, it is challenging to precisely control gaseous microenvironments in vitro for cell culture due to the high diffusivity nature of gases. In recent years, microfluidics has paved the way for the development of new types of cell culture devices capable of manipulating cellular microenvironments, and provides a powerful tool for in vitro cell studies. This paper reviews recent developments of microfluidic cell culture devices for the control of gaseous microenvironments, and discusses the advantages and limitations of current devices. We conclude with suggestions for the future development of microfluidic cell culture devices for the control of gaseous microenvironments.
Subjects
microfluidics; cell culture; gaseous microenvironment; PROTEIN-KINASE PATHWAY; NITRIC-OXIDE; OXYGEN GRADIENTS; HYDROGEN-SULFIDE; CARBON-MONOXIDE; ACUTE-HYPOXIA; PLATFORM; SYSTEM; CHIP; DYNAMICS
Publisher
IOP PUBLISHING LTD
Type
journal article