Choice Motivations Affecting Pregnant Women’s Acceptance of Amniocentesis or NIPT and the Needs of Genetic Counseling
Date Issued
2016
Date
2016
Author(s)
Lu, Hsian-Chun
Abstract
Amniocentesis and chorionic villus sampling are the main techniques of prenatal diagnosis. They are used to identify fetal chromosomal aneuploidies. The diagnosis of them is very accurate, but the invasive of which may cause intrauterine infection and abortion (0.1%~0.3%). Today the social phenomenon is late marriage, advanced maternal age, declining birthrate and rising the requirement of infertility treatment. The development of non-invasive prenatal diagnosis and high detection rate are very important in the future. NIPT (Non-invasive Prenatal Test) uses cell free fetal DNA from the plasma of pregnant women, and combines with new DNA sequencing technology. It has high sensitivity and specificity to common fetal trisomy 21 (Down syndrome, T21), trisomy 18 (Edwards syndrome, T18), trisomy 13 (Patau syndrome, T13). NIPT provides detection rates >99% and false-positive rates <0.1%. The study was aimed to discover the choice motivations affecting pregnant women’s acceptance of amniocentesis or NIPT, and the effectiveness of genetic counseling. 43 subjects were recruited using structured questionnaires at an obstetric clinic in Taipei. Among them, 23 women chose amniocentesis and 20 women chose NIPT. The structured questionnaire includes the demographic background, pregnancy experience, influencing factors, motive factors, and the knowledge scale of amniocentesis and NIPT. The results of the study were that comparing the motive factors about pregnant women’s accepting amniocentesis or NIPT. The pregnant women chose amniocentesis in the order of government subsidies, advanced maternal age, the cost of prenatal testing. Whereas, the pregnant women chose NIPT in the order of no miscarriage risk, test-tube baby, the suggestion of doctor. After genetic counseling, the scores of knowledge scale for amniocentesis and NIPT were increasing. It was significantly different (p<.001) in the groups. The study showed the genetic counseling had positive effect in rising cognition about amniocentesis and NIPT. The effectiveness of the genetic counseling was also significantly different. It showed the prenatal genetic counseling was necessary and helpful to pregnant women.
Subjects
Pregnant women
amniocentesis
NIPT(Non-invasive Prenatal Test)
trisomy
genetic counseling
Type
thesis