Genetic variants of NTCP gene and hepatitis B vaccine failure in Taiwanese children of hepatitis B e antigen positive mothers
Journal
Hepatology international
Journal Volume
16
Journal Issue
4
Pages
789
Date Issued
2022-08
Author(s)
Chen, Ya-Hui
Tsuei, Daw-Jen
Lai, Ming-Wei
Wen, Wan-Hsin
Chiang, Cheng-Lun
Abstract
Hepatitis B virus (HBV) vaccine failure remains a hurdle to the global elimination of HBV infections in the vaccination era. We aimed to elucidate the relationships between HBV entry receptor sodium taurocholate co-transporting polypeptide (NTCP) and vaccine failure in children born to highly infectious mothers.
Subjects
Chronic infection; Genetic variant; HBeAg seroconversion; HBsAg; Hepatitis B virus; IFITM3; NTCP; Type I interferons; Vaccine failure; rs4646287 G > A
SDGs
Publisher
SPRINGER
Type
journal article