Cytotoxic amides from Piper sintenense
Journal
Planta Medica
Journal Volume
68
Journal Issue
11
Pages
980-985
Date Issued
2002
Author(s)
CHE-MING TENG
Abstract
A new alkaloid, pipersintenamide ( 1), together with fourteen known compounds, have been isolated from the whole plant of Piper sintenense. The structures of these compounds were elucidated by spectroscopic analysis. Pipersintenamide, sintenpyridone, sarmentine, and 1-(3,4-methylenedioxyphenyl)-1 E-dodecene at 20 microg/ml exhibited effective cytotoxicities (cell survival < 15 %) against CCRF-CEM, HL-60, PC-3, and HA22T cell lines.
Type
journal article