AST-120 Improves Cardiac Dysfunction in Acute Kidney Injury Mice via Suppression of Apoptosis and Proinflammatory NF-κB/ICAM-1 Signaling
Journal
Journal of inflammation research
Journal Volume
14
Date Issued
2021
Author(s)
Abstract
Acute kidney injury (AKI) is a devastating disorder associated with considerably high morbidity and mortality. Reports have shown that AST-120, an oral charcoal adsorbent, can reduce oxidative stress by lowering serum indoxyl sulfate levels. The effects of AST-120 and indoxyl sulfate on kidney injury and cardiac dysfunction were investigated in vivo and in vitro.
Subjects
AST-120; NF-κB; acute kidney injury; apoptosis; cardiac dysfunction; inflammation
SDGs
Other Subjects
ast 120; brain natriuretic peptide; indican; intercellular adhesion molecule 1; interleukin 1beta; nitrogen; urea; acute kidney failure; animal experiment; animal model; animal tissue; apoptosis; Article; blood level; blood sampling; cardiac muscle cell; clinical article; clinical effectiveness; cohort analysis; controlled study; creatinine blood level; down regulation; echocardiography; enzyme linked immunosorbent assay; heart failure; heart left ventricle ejection fraction; heart output; histopathology; human; human cell; in vitro study; in vivo study; inflammation; kidney function; liquid chromatography; mouse; NF kappaB ICAM 1 signaling; nonhuman; oxidative stress; reperfusion injury; signal transduction; treatment duration; TUNEL assay; umbilical vein endothelial cell; urea nitrogen blood level; Western blotting
Type
journal article