Reanalysis of Trichloroethylene and Tetrachloroethylene Metabolism to Glutathione Conjugates Using Human, Rat, and Mouse Liver in Vitro Models to Improve Precision in Risk Characterization
Journal
Environmental Health Perspectives
Journal Volume
130
Journal Issue
11
Date Issued
2022-11
Author(s)
Valdiviezo, Alan
Brown, Grace E
Michell, Ashlin R
Trinconi, Cristiana M
Bodke, Vedant V
Khetani, Salman R
Chiu, Weihsueh A
Rusyn, Ivan
Abstract
Both trichloroethylene (TCE) and tetrachloroethylene (PCE) are high-priority chemicals subject to numerous human health risk evaluations by a range of agencies. Metabolism of TCE and PCE determines their ultimate toxicity; important uncertainties exist in quantitative characterization of metabolism to genotoxic moieties through glutathione (GSH) conjugation and species differences therein.
Publisher
National Institute of Environmental Health Sciences
Type
journal article