Colonic Leucine-Rich Repeat Kinase 2 Expression Is Increased and Associated With Disease Severity in Patients With Parkinson’s Disease
Journal
Frontiers in Aging Neuroscience
Journal Volume
13
Date Issued
2022
Author(s)
Liao, Peng-Hsiang
Chiang, Han-Lin
Hang, Jen-Fan
Abstract
BACKGROUND: ) comprise a common genetic risk factor for Parkinson's disease (PD) and inflammatory bowel disease (IBD). We investigated the expression of LRRK2 in colonic biopsies obtained from a cohort of PD patients and healthy controls. METHODS: A cohort of 51 PD patients and 40 age- and gender-matched controls who have colonic biopsied samples were recruited. Among these participants, 26 individuals (12 PD patients and 14 controls) had a series of colon biopsies. For the patients with PD, the first biopsies were taken before the PD diagnosis. The colonic expression of LRRK2 was assayed by immunohistochemical staining. RESULTS: < 0.01). CONCLUSION: Colonic LRRK2 expression was increased in PD patients compared to controls, and the expression level correlated with disease severity.
SDGs
Type
journal article