Cohort and Tumor Blood Flow Study of Breast Cancer
Date Issued
2008
Date
2008
Author(s)
Kuo, Wen-Hung
Abstract
Direction One: Incidence, Risk Factors and Survival Analysis Associated with Bilateral Breast Cancer in Area with Early Age Diagnosis but Low Incidence of Primary Breast Cancer: Analysis of 15-year Longitudinal Cohort in TaiwanAbstract Io examine the incidence and risk factors of bilateral breast cancer, a total of 120 and 1902 women with bilateral and unilateral breast cancers, respectively, were enrolled for this study. We selected various factors including individual patient medical history and life style to be the candidate risk parameters for increasing the rate of getting bilateral breast cancer. Using Kaplan-Meier method, we found the cumulative incidence for contralateral breast cancer diagnosed at 1, 3, 5 years after getting the primary breast cancer were 1.15%, 1.94%, and 2.97%, respectively. The significant risk factors were evaluated by their corresponding hazard ratio (HR) along with 95% confidence interval (CI). They were menopausal status (HR) =1.56; CI: 1.00-2.42), invasive lobular carcinoma (HR=2.98; CI: 1.35-6.56), chemotherapy (HR=2.21; CI:1.43-3.42) and radiotherapy (HR=3.32; CI: 2.19-5.05). However, a significant protective factor was identified to be Tamoxifen therapy (HR=0.5; CI: 0.34-0.74). Size of the secondary tumor (2.97 cm) was found to be smaller than the first one (3.58 cm) but with borderline statistical significance (p=0.0731). Comparing to the existing data in western world, we found a higher risk for developing contralateral breast cancer in Taiwan, where a significant low incidence of primary breast cancer for young women is noted. It suggested that both factors, primary breast tumor onset at early age and lobular carcinoma, are found more likely to develop bilateral breast cancers. retrospective cohort study was designed to follow Taiwanese women (N=1907) with primary breast cancer diagnosed between 1990 and 1999 from National Taiwan University Hospital until December 24th, 2004. They included 1863 unilateral breast cancer and 44 bilateral breast cancer. The mean age of diagnosis as breast cancer for this cohort was 48.71 (
Subjects
breast cancer
bilateral breast cancer
risk factor, incidence
survival
advanced breast cancer
angiogenesis
neoadjuvant chemotherapy
power Doppler sonography
vascularity index
SDGs
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