Genetic interaction analysis of TCF7L2 for biochemical recurrence after radical prostatectomy in localized prostate cancer
Journal
International Journal of Medical Sciences
Journal Volume
12
Journal Issue
3
Pages
243-247
Date Issued
2015
Author(s)
Abstract
Backgroud: Accumulated evidence has demonstrated a significant role of the Wnt pathway in human prostate cancer. We hypothesize that genetic variants in the Wnt pathway effector, Transcription factor 7-like 2 (TCF7L2), may influence clinical outcomes in prostate cancer. Methods: We comprehensively selected 12 tagged single-nucleotide polymorphisms (SNPs) to capture majority of common variants across TCF7L2, and genotyped in 458 localized prostate cancer patients treated with radical prostatectomy (RP). Kaplan-Meier analysis, Cox proportional hazard model, and survival tree analyses were performed to identify significant SNPs that correlated with biochemical recurrence (BCR) after surgery. Results: A higher-order SNP-SNP interaction profile consisting of TCF7L2 rs7094463, rs10749127, and rs11196224 was significantly associated with BCR (Ptrend= 0.001). After adjusting for possible confounders, the genetic profile remained significant (Ptrend= 0.007). None of the studied SNPs were individually associated with BCR. Conclusions: Our results support a genetic interaction in the TCF7L2 SNPs as a predictor of disease recurrence after curative RP in localized prostate cancer patients. ? 2015 Ivyspring International Publisher.
Subjects
Biochemical recurrence; Prostate cancer; Radical prostatectomy; Single-nucleotide polymorphism; TCF7L2; Wnt pathway
SDGs
Other Subjects
transcription factor 7 like 2; TCF7L2 protein, human; transcription factor 7 like 2; adult; aged; Article; biochemical recurrence free survival; cancer prognosis; cancer recurrence; gene; gene expression; gene interaction; genetic association; genetic variability; genotype; human; major clinical study; male; prostate cancer; prostatectomy; single nucleotide polymorphism; Taiwanese; TCF7L2 gene; disease free survival; genetics; Kaplan Meier method; middle aged; pathology; prognosis; Prostatic Neoplasms; tumor recurrence; Wnt signaling pathway; Aged; Disease-Free Survival; Humans; Kaplan-Meier Estimate; Male; Middle Aged; Neoplasm Recurrence, Local; Polymorphism, Single Nucleotide; Prognosis; Prostatectomy; Prostatic Neoplasms; Transcription Factor 7-Like 2 Protein; Wnt Signaling Pathway
Publisher
Ivyspring International Publisher
Type
journal article