eIF3k 調控細胞凋亡之分子機制與功能探討
Study of The Function and Molecular Mechanism of eIF3k in Apoptosis Regulation
Date Issued
2005
Date
2005
Author(s)
Chen, Yi-Ru
DOI
en-US
Abstract
eIF3k, a 28 kDa protein, is the smallest subunit of eukaryotic translation initiation factor 3 complex and is evolutionally conserved among higher eukaryotes, including mammals, insects, worms and plants. However, genetic and biochemical studies failed to demonstrate an essential role of eIF3k in general translation. Here, we identified a novel function of eIF3k in promoting apoptosis, as knockdown of endogenous eIF3k could de-sensitize cells to several apoptotic stimuli, such as UV irradiation
Subjects
真核生物轉譯因子3k
細胞凋亡
角質蛋白8號 (K8) 和18號 (K18)
eIF3k
cytokeratin K8/K18
Apoptosis
Type
other
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