Synthesis, structure and anti-acetylcholinesterase activity of 4β-methoxymethyl-4β-demethyl territrem B
Journal
Mycopathologia
Journal Volume
137
Journal Issue
2
Pages
125-128
Date Issued
1997
Author(s)
Abstract
4beta-Methoxymethyl-4beta-demethyl territrem B [5] was synthesized from 4beta-hydroxymethyl-beta-demethyl territrem B [4] by treatment with dimethyl sulfate in methanolic NaOH. The structure of 5 was elucidated by uv, nmr and mass spectra. The IC50 of 5 on acetylcholinesterase (AChE) was 6.30 x 10(-5) M, which indicated 0.4% of the anti-AChE activity of territrem B [2].
SDGs
Type
journal article