Red mold dioscorea has a greater antihypertensive effect than traditional red mold rice in spontaneously hypertensive rats
Journal
Journal of Agricultural and Food Chemistry
Journal Volume
57
Journal Issue
11
Pages
5035-5041
Date Issued
2009
Author(s)
Abstract
The aim of this study is to investigate the antihypertensive effects of red mold rice (RMR) and red mold dioscorea (RMD) by low-dose oral administration to spontaneously hypertensive rats (SHRs). A single oral dose of 1-fold RMD (150 mg/kg) significantly (p < 0.05) decreased systolic blood pressure (SBP) and diastolic blood pressure (DBP) after 8 h of administration, but RMR showed no significant effect. During the chronic oral administration of 1-fold RMR (150 mg/kg), 0.5-fold RMD, 1-fold RMD, and 5-fold RMD to SHRs for 8 weeks, the increase of blood pressure was slowed significantly. The results indicated that only a 0.5-fold dose of RMD was able to significantly decrease both SBP and DBP. A 1-fold RMD showed a greater antihypertensive effect than 1-fold RMR, and both RMR and RMD can improve the vascular elastin structure remodeling. In comparison to RMR, RMD contained a higher amount of γ-aminobutyric acid (GABA) and anti-inflammatory yellow pigments (monascin and ankaflavin). Moreover, RMD also exhibited higher angiotensin-l-converting enzyme (ACE) inhibitory activity than RMR. These results suggest that RMD has greater antihypertensive bioavailability. ? 2009 American Chemical Society.
Subjects
γ-aminobutyric acid; Angiotensin-l-converting enzyme; Antihypertensive effect; Diastolic blood pressure; Monascus; Red mold dioscorea; Red mold rice; Spontaneously hypertensive rats; Systolic blood pressure
SDGs
Other Subjects
antihypertensive agent; plant extract; animal; article; blood pressure; chemistry; comparative study; disease model; drug effect; human; hypertension; male; metabolism; microbiology; Monascus; pathophysiology; rat; rice; spontaneously hypertensive rat; yam; Animals; Antihypertensive Agents; Blood Pressure; Dioscorea; Disease Models, Animal; Humans; Hypertension; Male; Monascus; Oryza sativa; Plant Extracts; Rats; Rats, Inbred SHR; Dioscorea; Dioscorea alata; Monascus; Rattus
Type
journal article