Impact of Chronic Hepatitis B and D Infection on the Outcomes of Patients with Human Immunodeficiency Virus Infection

Co-infections with human immunodeficiency virus (HIV) and hepatitis B virus (HBV) are common because of sharing similar transmission routes. The influences of HBV infection on the responses to highly active antiretroviral therapy (HAART) and hepatic complications of patients with HIV infection remain uncertain. Taiwan is a hyperendemic area of HBV infection with chronic HBsAg carriage occurred in 15% to 20% of general population. With the introduction of HAART in 1996, improved survival of HIV-infected patients may allow complications and liver deaths occurred related to HBV. To understand the impact of HBV on HIV-infected patients in Taiwan, HIV-infected patients at National Taiwan University Hospital from 1994 to 2005 were studied.