A Novel Method for Screening G-quadruplex Stabilizers to Human Telomeres
Resource
JOURNAL OF THE CHINESE CHEMICAL SOCIETY, 58(3), 296-230
Journal
Journal of the Chinese Chemical Society
Pages
296-300
Date Issued
2011
Date
2011
Author(s)
Chu, Jen-Fei
Wang, Zi-Fu
Tseng, Ting-Yuan
Chang, Ta-Chau
Abstract
Abstract We present a simple method based on the Cu 2+ induced unfolding of G‐quadruplex (G4) of human telomere sequence d[AG 3 (T 2 AG 3 ) 3 ] to screen a number of 3,6‐bis(1‐methyl‐4‐vinylpyridinium)carbazole diiodide (BMVC) analogues for better G4 stabilizers. Using circular dichroism (CD), the screening results suggest that the tri‐cations of 9‐substituted BMVC derivatives are better G4 stabilizers than the bi‐cations of BMVC. In addition, 3,6‐bis(1‐methyl‐4‐vinylpyrazinium)carbazole diiodide (BMVC4) is likely a better core molecule than BMVC for G4 stabilizers.
Type
journal article
File(s)![Thumbnail Image]()
Loading...
Name
124.pdf
Size
23.23 KB
Format
Adobe PDF
Checksum
(MD5):a87c4fbe480f83551d3ed0e27479aa5f