An efficient preparation of N-acetyl enamides catalyzed by Ru(II) complexes
Journal
Tetrahedron
Journal Volume
69
Journal Issue
1
Pages
268-273
Date Issued
2013
Author(s)
Abstract
Reductive acetylation of ketoximes to give the corresponding acyl enamides can be achieved by using 1-3 mol % of [RuCl2(p-cymene)]2 as the catalyst in the presence of KI as the reducing agent in high yields. This procedure has been applied to synthesize N-[1-(1,3-benzodioxol-5-yl)-1-butenyl] acetamide (6), which is the intermediate for the synthesis of DMP 777, an inhibitor of leukocyte elastase. © 2012 Elsevier Ltd. All rights reserved.
SDGs
Type
journal article