Feasibility Study on Continuous Nonenzymatic Sensors for Glucose Sensing
Date Issued
2016
Date
2016
Author(s)
Li, Chang-Long
Abstract
Glucose concentration in human bodies is gold criteria for Diabetes Mellitus of diagnosis and treatment. The conventional glucose sensors are utilized enzyme electrode to sensing glucose moleculars. However, the conventional enzyme glucose sensors are difficult to synthesis , store and long-term stay in human bodies. In this research, we attempt using non-enzymatic platinum-Iridium(Pt-Ir) glucose sensor to replace conventional glucose sensors and look forward to applicate in continuous glucose monitoring(CGM). The research were separated into two parts, the first is the fabrication of platinum-Iridium glucose sensor and its feasibility test, including sensitivity, linearity and interference test. The substrate of the electrode is come from TaiDoc Technology and then using galvanostatic method to electroplate the nano-structure of Pt-Ir. The leaf-like of the nano-structure is believed that can increase the catalytic reaction area. The second part is the animal test, the electrodes were implanted into the subcutaneous of mice to test the stability and life cycle.
Subjects
Diabetes Mellitus
non-enzymatic glucose sensor
continuous glucose sensor
nano-structure
mice implant
SDGs
Type
thesis