Prevalence & prognosis value of TET2 gene polymorphisms in childhood acute myeloid leukemia
Date Issued
2011
Date
2011
Author(s)
Li, Meng-Ju
Abstract
Background and Purpose. Acute myeloid leukemia (AML) accounts for 10% of childhood leukemia. The tet oncogene family member 2 (TET2) gene mutations are found in adult AML and is associated to prognosis. However, the report in childhood AML is limited. Here, we assess the prevalence of TET2 polymorphism in childhood AML and to identify its association with prognosis.
Method. We collected pediatric patients in national Taiwan university hospital from January 1997 to June 2010. DNA was isolated from bone marrow cells at diagnosis and sequence analysis was carried out for TET2 gene. Chi-square, t-test, Kaplan-Meier survival method and regression analysis are used for testing the association of TET2 polymorphisms with clinical presentation and prognosis.
Result. Total of 56 pediatric AML patients were enrolled. The mean age is 9.07 ± 5.4 (0.01~17.54) years. There are 34 (60.7%) males. Twenty-four (42.9%) patients had relapse and the overall survival rate is 45%. The prevalence of TET2 polymorphism is 78.6% (44/56). There was no association between TET2 polymorphism to clinical presentation or prognosis.
Conclusions. The prevalence of TET2 mutation in pediatric AML patients is far lower than in adults and is not associated with clinical presentation or prognosis.
Subjects
Acute myeloid leukemia
Pediatric
TET2
Single nucleotide polymorphism
Type
thesis
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