Second Asian Consensus Report on Functional Dyspepsia (2025): Updated Recommendations.
Journal
Journal of gastroenterology and hepatology
Journal Volume
41
Journal Issue
3
Start Page
832
End Page
853
ISSN
1440-1746
Date Issued
2026-03
Author(s)
Mahadeva, Sanjiv
Siah, Kewin Tien Ho
Ghoshal, Uday C
Suzuki, Hidekazu
Lee, Yeong Yeh
Chuah, Kee Huat
Chung, Vincent
Zhong, Linda
Tay, Benjamin Wei-Rong
Ang, Ban Hong
Sinnanaidu, Ram Prasad
Bai, Tao
Oshima, Tadayuki
Patcharatrakul, Tanisa
Sachdeva, Sanjeev
Liu, Jinsong
Xiao, Yinglian
Vilaichone, Ratha-Korn
Lee, Joon Seong
Oh, Jung-Hwan
Syam, Ari Fahrial
Lu, Ching Liang
Ang, Tiing Leong
Sung, In-Kyung
Hou, Xiao-Hua
Sugano, Kentaro
Wu, Justin
Miwa, Hiroto
Abstract
Background: Functional dyspepsia (FD) is a common gastrointestinal disorder that significantly impacts patients' quality of life. Over a decade ago, the Asian Neurogastroenterology and Motility Association (ANMA) and the Asian Pacific Association of Gastroenterology (APAGE) jointly developed the first Asian consensus report on FD. In this consensus report, members of ANMA and APAGE provide updated recommendations on the definition, diagnosis, epidemiology, pathophysiology, and management of FD, focusing on Asian populations. Methods: The task force members conducted a systematic literature review and used a modified Delphi process to develop updated consensus statements. Based on members' feedback, statements that failed to reach at least 80% consensus in the first round of voting were revised. Revisions included rephrasing for clarity, incorporating additional evidence, and subgroup voting during a second round of discussion at a hybrid meeting. Results: The task force developed 32 statements covering key aspects of FD. Major updates include new insights into the pathophysiology and emerging treatment options. The task force acknowledged that the limited scope and heterogeneity of available studies limit definitive conclusions about the utility of some emerging therapies such as probiotics and potassium-competitive acid blockers in FD management. Conclusions: The second Asian Consensus Report on FD provides updated evidence-based recommendations to improve the diagnosis and management of FD in clinical practice, particularly in the Asian setting.
Subjects
Asia
consensus
diagnosis
epidemiology
functional dyspepsia
management
pathophysiology
Type
review article