Effects of citrus polyphenol on oral ulcer and oral cancer cells
Date Issued
2015
Date
2015
Author(s)
Tsai, Hsiao-Cheng
Abstract
In clinical, many factors could cause the oral ulcer occurring, including the two major factors ─ periodontal disease and oral cancer. It indicated that oral ulcer is high correlated with periodontal disease and oral cancer. Various polyphenolic compounds from plant or fruit are confirmed that they have different pharmaceutical functions. The purposes of this study were to evaluate the effects of citrus polyphenol (CP) on dental applications. In our study, the culture medium with CP was developed to improve the wound healing of fibroblasts and inhibit the growth of oral cancer cell. Our results show that, in the low concentration, CP will have an enhancing regenerative function for oral ulcer, and high concentration CP also shows a growth-inhibiting function for oral cancer cell. Therefore, the CP would be used to be a supplemental compound in mouthwash for oral ulcers and periodontal diseases. In addition, after curing the periodontal diseases, bone defect will happen on some patient. Guide bone regeneration (GBR) was widely used method for repairing bone lost from periodontal disease. But, there were some disadvantages exhibiting in the GBR method such as needing a stable barrier membrane and a new creative cavity during surgical process. To solve these disadvantages, the other purpose of this study was to develop the novel micro-injector, which is designed to carry bone graft substitutes to restore bone defects for bone regeneration in periodontal diseases. We hope the device would be used to replace the GBR method. The major contributions of our thesis are that we confirmed the feasibility of CP to be a supplemental compound for topical application onto the healing of oral ulcer, inhibiting proliferation and migration of oral cancer cell, and the feasibility of this novel micro-injector carried bone graft substitutes to restore the bone defects of periodontal tissue in dental application.
Subjects
citrus polyphenol
oral ulcer
oral cancer
micro-injector
SDGs
Type
thesis