Progress in Biomimetic Microdevices for Anticancer Drug Screening and their Potential for Enhancing In Vivo Efficacy
Journal
Advanced NanoBiomed Research
Journal Volume
2025
ISSN
2699-9307
Date Issued
2025-05-14
Author(s)
Abstract
The development of effective anticancer drugs remains a critical challenge despite significant advancements in technology and medicine. In this review, we explore the progress made in leveraging biomimetic microdevices for anticancer drug screening and their potential to enhance in vivo efficacy. Specifically, we discuss the utilization of innovative platforms such as xenograft models, patient-derived xenografts, humanized immune system models, and transgenic models, alongside conventional multiwell plates, to mimic the tumor microenvironment and cellular interactions more accurately. Through the integration of advanced technologies, researchers have achieved remarkable improvements in drug screening, efficacy prediction, and identification of optimal drug combinations. This review provides insights into the strengths and limitations of these biomimetic microdevices compared to conventional multiwell plates, offering perspectives on their future role in personalized cancer medicine.
Subjects
biomimetic
drug screening
microdevices
xenografts
SDGs
Publisher
Wiley
Type
review