Impact of peripheral muscle strength on prognosis after extubation and functional outcomes in critically ill patients: a feasibility study
Journal
Scientific reports
Journal Volume
11
Journal Issue
1
Date Issued
2021
Author(s)
Abstract
The influence of peripheral muscle strength on prognosis after extubation and subsequent functional outcomes is not evident. The objectives of this study were to determine (1) whether peripheral muscle strength can be used as a predictor for patients' prognoses after extubation, and (2) whether the peripheral muscle strength before extubation is correlated with patients' subsequent ambulation ability and in-hospital mortality. This study was a prospective observational cohort study. A hand-held dynamometer was used for evaluated the muscle strength of the biceps and quadriceps right before extubation. Besides, after the patients had been transferred from the ICU to the general ward, a 2-minute walk test was performed. A total of 52 patients were enrolled in this study, and the rate of extubation failure was 15%. The muscle strength of the quadriceps was significantly correlated with the prognosis after extubation, 48% of the patients were able to ambulate after being transferred to the general ward. The overall mortality rate was 11%, and there was a significant correlation between the biceps muscle strength and in-hospital mortality. Peripheral muscle strength may serve as an important predictor of a patients' prognoses after extubation. Poor peripheral muscle strength is indicative of not only a higher risk of re-intubation but also higher in-hospital mortality and poorer functional outcomes.Trial registration: ISRCTN16370134. Registered 30 May 2019, prospectively registered. https://www.isrctn.com/ISRCTN16370134 .
Subjects
INTENSIVE-CARE-UNIT; 2-MINUTE WALK TEST; COUGH PEAK FLOW; BODY-MASS INDEX; LENGTH-OF-STAY; MECHANICAL VENTILATION; HOSPITAL MORTALITY; HANDGRIP STRENGTH; ACQUIRED WEAKNESS; RE-INTUBATION
SDGs
Other Subjects
aged; critical illness; extubation; feasibility study; female; human; intensive care unit; length of stay; male; mortality; muscle strength; pathophysiology; physiology; procedures; prognosis; prospective study; skeletal muscle; Aged; Airway Extubation; Critical Illness; Feasibility Studies; Female; Humans; Intensive Care Units; Length of Stay; Male; Muscle Strength; Muscle, Skeletal; Prognosis; Prospective Studies
Publisher
NATURE PORTFOLIO
Type
journal article