The study of the knowledge, attitudes, and decision making towards clinical trials in cancer patients
Date Issued
2011
Date
2011
Author(s)
Wu, Ming-Tzu
Abstract
Since present anti-cancer therapies still have their limitation, nowadays more and more cancer patients would be invited or suggested to consider participating in clinical trial. This study was aim to explore the knowledge, attitudes, behavior intention, and decision making process towards clinical trials on cancer patients in Taiwan (R.O.C.). A cross-sectional, observational, and co-relational study has conducted during 2011 February to 2011 June in a medical center located in north Taiwan. The information was collected using structured questionnaires which was composed of following 5 scales: (1) Clinical trial Knowledge scale, (2) Attitude toward randomized clinical trials scale, (3) Shared Decision Making (SDM-Q-9), (4) Satisfaction with Decision (SWD-scale), and (5) Decision Regret scale (DRS). All of these scales have the permission of translation and showed great reliability (Cronbach’s alpha, 0.82~0.89) in this study. A total number of 117 lung cancer and liver cancer patients, who have experienced the treatment clinical trials'' informed consent process in 6 months, were recruited. But 6 did not complete the questionnaire due to physical reason. Therefore 111 data from patient were be analyzed in our study.
Result: Among 111 cancer patients sampled, most of them show great attitude, shared decision making level and high satisfaction, as well as low decisional regret feeling. Meanwhile, they show high behavior intention (74.8%) to consider participating in clinical trials. In addition, our study demonstrated the fact that patients who are more likely to participate in cancer clinical trials would have following predictors: male, high educational level, great attitudes toward clinical trial, and high satisfaction with decision making about whether to participate in trials( Adjusted R2 = 0.335, p < 0.000). However, patients who had more experience on participating clinical trials would have both higher level of decisional regret perception (x2=2.58, p=0.01) and lower level of satisfaction with decision.
Our study suggested that clinical trials medical workers can reinforce the level of shared decision making and satisfaction with decisions through taking some steps in following aspects: provide the alternative treatments options and the process or purpose about randomized allocation in necessary, as well as discuss the whole medical condition with patients and try to understand patients’ preference. So that medical worker would improved patients'' autonomy, satisfaction with the decision making and communication process between patients and medical professors whenever cancer patients consider participating in clinical trials.
Subjects
shared decision making
clinical trials
attitude and knowledge towards
clinical trial
behavior intention
Decision Regret
SDGs
Type
thesis
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