Anti-neuroinflammatory polyketides from the medicinal herb-derived fungal strain Didymocyrtis brachylaenae Km1530
Journal
Journal of Food and Drug Analysis
Journal Volume
33
Journal Issue
3
Start Page
302
End Page
311
ISSN
2224-6614
Date Issued
2025-09-17
Author(s)
Chang, Chia-Hao
Zhang, Yun-Rong
Huang, Shu-Jung
Hsiao, George
Chi, Wei-Chiung
Gu, Andrea
Lai, Yu-Wei
Abstract
A series of chromatographic separation on the liquid-state fermented products of Didymocyrtis brachylaenae Km1530 derived from the littoral medicinal herb Atriplex maximowicziana Makino, resulted in the isolation of compounds 1—13. Their structures were determined by spectroscopic analysis as five previously unreported C13 polyketides, namely brachylactones A—D (1—4) and brachic acid (5), along with eight known compounds 6—13. Among these, brachylactones A (1) and B (2) exhibited nitric oxide production inhibitory activity in lipopolysaccharide-induced murine BV2 microglial cells at a concentration of 20 μM without any cytotoxicity.
Subjects
Anti-neuroinflammation
Brachylactone
Didymocyrtis brachylaenae
Nitric oxide
Polyketide
SDGs
Publisher
The Journal of Food and Drug Analysis (JFDA), Food and Drug Administration, Taiwan (TFDA)
Type
journal article