Fatty acid binding protein 2 and insulin resistance
Journal
European Journal of Clinical Investigation
Journal Volume
31
Journal Issue
6
Pages
521-527
Date Issued
2001
Author(s)
Abstract
Background: An A54T polymorphism of the fatty acid binding protein 2 (FABP2) gene was found to be associated with insulin resistance in nondiabetic Pima Indians. Design: This is a cross-sectional study to examine the role of this polymorphism in insulin resistance in 71 healthy and normotensive Caucasian subjects with normal glucose tolerance. Insulin sensitivity (%S, ISIM, ISIS) and beta-cell function (%B, dI/dG, 1stPHS, 2ndPHS) were estimated based on published models. Their genotypes were determined using a polymerase chain reaction-restriction fragment length polymorphism assay. The relationship between genotypes and phenotypes was examined. Results: After genotyping, we identified 34 AA, 32 AT and five TT subjects. The TT subjects were pooled together with the AT subjects during the analysis due to their low number. No difference was noted in gender distribution, clinical features, or fasting lipid profile between the two genotypic groups (AA vs. AT/TT). The AT/TT group had lower %S and ISIS than the AA group (P = 0.0118 and P = 0.0170, respectively). The difference in ISIM was marginal (P = 0.0544). However, no difference was noted in beta-cell function between the two groups. Multivariate analysis revealed that this polymorphism was an independent but modest determinant for %S (P = 0.0149), ISIM (P = 0.0489) and ISIS (P = 0.0175). It independently contributed 6.04% (95% CI, 0.02-20.53%), 4.28% (95% CI, 0.08-17.63%) and 4.94% (95% CI, 0.01-18.75%) of the variation of %S, ISIM and ISIS, respectively. Conclusions: We demonstrated that the A54T polymorphism at the FABP2 locus is a risk factor for insulin resistance in a Caucasian population.
SDGs
Other Subjects
fatty acid binding protein; fatty acid binding protein 2; unclassified drug; adult; American Indian; article; body mass; Caucasian; DNA polymorphism; female; gene locus; genotype; human; insulin resistance; insulin sensitivity; male; multivariate analysis; pancreas islet beta cell; polymerase chain reaction; priority journal; restriction fragment length polymorphism; risk factor; Adult; Carrier Proteins; Cross-Sectional Studies; European Continental Ancestry Group; Fatty Acid-Binding Proteins; Fatty Acids; Female; Genotype; Glucose Tolerance Test; Humans; Insulin Resistance; Male; Mexican Americans; Neoplasm Proteins; Phenotype; Polymorphism, Genetic; Tumor Suppressor Proteins
Type
journal article