Setting up presynaptic structures at specific positions
Journal
Current Opinion in Neurobiology
Journal Volume
20
Journal Issue
4
Pages
489-493
Date Issued
2010
Author(s)
Shen K.
Abstract
Precise formation of presynaptic structures at specific loci is critical for correctly wiring neuronal circuits. Recent findings have gradually revealed how essential cues from different sources inform the axon to define the presynaptic domain and to choose its postsynaptic target. Here, we review key molecular regulators which mediate instructive or repellent signals from multiple sources including the target cells, local guidepost cells, and distal guiding tissues.
Type
review