A Cell-Capacitance-Insensitive CMOS Sample-and-Hold Chronoamperometric Sensor for Real-Time Measurement of Small Molecule Drugs in Whole Blood
Journal
Digest of Technical Papers - IEEE International Solid-State Circuits Conference
Journal Volume
2020-February
Pages
406 - 408
Date Issued
2020
Author(s)
Abstract
The capability of adjusting a drug-dosing profile in real time based on personalized pharmacokinetics plays a crucial role in achieving optimal therapeutic outcomes at minimal toxicity [1]. Achieving this requires biosensors that can continuously measure drug concentrations at sub-minute temporal resolution. Today, the gold standard methods such as immunoassays and liquid chromatography are not able to achieve this because they require long assay times (typically hours). Recently, structure-switching aptamers have drawn great attention for in vivo realtime monitoring [2]-[4]. As shown in Fig. 26.4.1, aptamers are single-stranded DNA molecules whose sequences are selected to bind target molecules with high affinity [2]. To achieve electrochemical detection, redox reporters (such as methylene blue, MB) are conjugated to these aptamers such that conformation changes in the aptamer caused by target binding leads to a direct electrical readout in proportional to the target concentration. Such a reagent-free capability has been demonstrated using microfluidics and implanted probes measuring chemotherapeutics and aminoglycoside antibiotics [2]-[4]. To generalize the technology for ambulatory patients, [5] presents a system integrating an aptamer-interfacing electrochemical circuit with wireless powering and telemetry. © 2020 IEEE.
Event(s)
2020 IEEE International Solid-State Circuits Conference, ISSCC 2020
SDGs
Other Subjects
Aromatic compounds; Chemical detection; CMOS integrated circuits; DNA; DNA sequences; Organic polymers; Aminoglycoside antibiotics; ELectrochemical detection; Real time measurements; Real time monitoring; Single-stranded DNA molecules; Small-molecule drugs; Target concentrations; Therapeutic outcomes; Liquid chromatography
Type
conference paper