An on-Line Quantitative Immunoassay System Based on a Quartz Crystal Microbalance
Resource
JOURNAL OF IMMUNOLOGICAL METHODS v.239 n.1-2 pp.121-124
Journal
JOURNAL OF IMMUNOLOGICAL METHODS
Journal Volume
v.239
Journal Issue
n.1-2
Pages
121-124
Date Issued
2000
Date
2000
Author(s)
Lin, Shiming
Lu, Chih-Cheng
Chien, Hsiung-Fei
Abstract
We have established a QCM immunoassay system which allows on -line and quantitative monitoring throughout the entire detection procedure and provides information on the surface coverage and the binding ratio of antibody to antigen. Compared to conventional immunoassay systems the QCM system offers advantages of short response times, obviates the need for additive labeling reagents, and permits direct conversion of a frequency signal into mass accumulation. (C) 2000 Elsevier Science B.V. All rights reserved
Subjects
quartz crystal microbalance
immunoassay
polythiolation
binding ratio
Type
journal article