Trans-ethnic fine mapping identifies a novel independent locus at the 3′ end of CDKAL1 and novel variants of several susceptibility loci for type 2 diabetes in a Han Chinese population
Journal
Diabetologia
Journal Volume
56
Journal Issue
12
Pages
2619
Date Issued
2013-12
Author(s)
Kuo, Jane Z
Sheu, Wayne Huey-Herng
Assimes, Themistocles L
Hung, Yi-Jen
Absher, Devin
Chiu, Yen-Feng
Mak, Jordan
Wang, Jun-Sing
Kwon, Soonil
Goodarzi, Mark O
Lee, I-Te
Knowles, Joshua W
Miller, Brittany E
Lee, Wen-Jane
Guo, Xiuqing
Taylor, Kent D
Hsiung, Chao A
Quertermous, Thomas
Rotter, Jerome I
Chen, Yii-Der I
Abstract
Candidate gene and genome-wide association studies have identified ∼60 susceptibility loci for type 2 diabetes. A majority of these loci have been discovered and tested only in European populations. The aim of this study was to assess the presence and extent of trans-ethnic effects of these loci in an East Asian population.
Subjects
Ethnic difference; Genetic association; Type 2 diabetes; GENOME-WIDE ASSOCIATION; RISK LOCI; INSULIN-RESISTANCE; FASTING GLUCOSE; GENE; IGF2BP2; SLC30A8; VISUALIZATION; CDKN2A/B; TRAITS
Publisher
SPRINGER
Type
journal article