Two approaches for test of linkage disequilibrium in pedigree data
Date Issued
2004
Date
2004
Author(s)
Yen, Chia- Hsin
DOI
zh-TW
Abstract
There are two types of data structures for linkage disequilibrium, family data and population data. Testing linkage disequilibrium using the family data should be more powerful than population data if the genetic markers and disease-susceptibility locus were linkage. And there are two types of the family data, triad families and pedigrees. Naturally, testing linkage in the pedigrees should be more powerful since there is at least one affected child and we can get more information from a pedigree. Based on the transmission disequilibrium test (TDT) many authors developed linkage testing in different data structures even to general pedigrees, one of these statistics is pedigree disequilibrium test (PDT). In this study we constructed two statistics which are more powerful and different from PDT statistic for testing linkage disequilibrium in pedigrees.
Subjects
三元體資料
家族資料
PDT統計量
TDT統計量
連鎖不平衡
pedigree
triad
PDT
linkage disequilibrium
TDT
Type
thesis
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