Deep brain stimulation rectifies the noisy cortex and irresponsive subthalamus to improve parkinsonian locomotor activities
Journal
NPJ Parkinson's disease
Journal Volume
8
Journal Issue
1
Start Page
77
ISSN
2373-8057
Date Issued
2022-12
Author(s)
Lee, Lan-Hsin Nancy
Huang, Chen-Syuan
Wang, Ren-Wei
Chung, Chih-Ching
Yang, Ya-Chin
Abstract
The success of deep brain stimulation (DBS) therapy indicates that Parkinson's disease is a brain rhythm disorder. However, the manifestations of the erroneous rhythms corrected by DBS remain to be established. We found that augmentation of α rhythms and α coherence between the motor cortex (MC) and the subthalamic nucleus (STN) is characteristically prokinetic and is decreased in parkinsonian rats. In multi-unit recordings, movement is normally associated with increased changes in spatiotemporal activities rather than overall spike rates in MC. In parkinsonian rats, MC shows higher spike rates at rest but less spatiotemporal activity changes upon movement, and STN burst discharges are more prevalent, longer lasting, and less responsive to MC inputs. DBS at STN rectifies the foregoing pathological MC-STN oscillations and consequently locomotor deficits, yet overstimulation may cause behavioral restlessness. These results indicate that delicate electrophysiological considerations at both cortical and subcortical levels should be exercised for optimal DBS therapy.
Subjects
LOW-FREQUENCY OSCILLATIONS; IMPULSE CONTROL DISORDERS; PRIMARY MOTOR CORTEX; BASAL GANGLIA; NUCLEUS STIMULATION; BETA-OSCILLATIONS; FUNCTIONAL CONNECTIVITY; SENSORIMOTOR CORTEX; IN-VITRO; DISEASE
SDGs
Publisher
NATURE PORTFOLIO
Type
journal article