In-vivo Evaluation of a Chitosan/γPGA Hydrogelressing in Post-extraction Sockets
Date Issued
2008
Date
2008
Author(s)
Chuang, Yu-Horng
Abstract
A novel chitosan/γPGA Hydrogel was composed of chitosan and γPGA because chitosan had antiseptic, biocompatible, and degradable properties and γPGA’s anionic nature allowed γPGA to form hydrogel with chitosan at an appropriate pH. The purpose of in-vivo study was to evaluate the chitosan/γPGA Hydrogel’s degradation rate, wound healing situation and new bone formation by radiography and histology. Fifty female Wistar rats (total 100 upper incisors) were used as the animal model. We chose randomly 64 extraction sockets and they were divided into 4 groups: no implant insertion(control group), Spongostan(control group), chitosan sponge(experiment group), chitosan/γPGA Hydrogel(experiment group).The rats were sacrificed later at the time interval of 1, 2 ,4, 6 weeks for further radiographic and histological evaluations. The results showed the chitosan/γPGA Hydrogel’s effect on new bone formation was better than other 3 groups.
Subjects
extraction sockets
chitosan
γPGA
hydrogel
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