Wsg, a glucose-rich polysaccharide from ganoderma lucidum, combined with cisplatin potentiates inhibition of lung cancer in vitro and in vivo
Journal
Polymers
Journal Volume
13
Journal Issue
24
Start Page
4353
ISSN
20734360
Date Issued
2021
Author(s)
Qiu, Wei-Lun
Hsu, Wei-Hung
Tsao, Shu-Ming
Tseng, Ai-Jung
Lin, Zhi-Hu
Hua, Wei-Jyun
Yeh, Hsin
Chen, Chien-Chang
Chen, Li-Sheng
Lin, Tung-Yi
Abstract
Lung cancer has the highest global mortality rate of any cancer. Although targeted therapeutic drugs are commercially available, the common drug resistance and insensitivity to cisplatin-based chemotherapy, a common clinical treatment for lung cancer, have prompted active research on alternative lung cancer therapies and methods for mitigating cisplatin-related complications. In this study, we investigated the effect of WSG, a glucose-rich, water soluble polysaccharide derived from Ganoderma lucidum, on cisplatin-based treatment for lung cancer. Murine Lewis lung carcinoma (LLC1) cells were injected into C57BL/6 mice subcutaneously and through the tail vein. The combined administration of WSG and cisplatin effectively inhibited tumor growth and the formation of metastatic nodules in the lung tissue of the mice. Moreover, WSG increased the survival rate of mice receiving cisplatin. Co-treatment with WSG and cisplatin induced a synergistic inhibitory effect on the growth of lung cancer cells, enhancing the apoptotic responses mediated by cisplatin. WSG also reduced the cytotoxic effect of cisplatin in both macrophages and normal lung fibroblasts. Our findings suggest that WSG can increase the therapeutic effectiveness of cisplatin. In clinical settings, WSG may be used as an adjuvant or supplementary agent. © 2021 by the authors. Licensee MDPI, Basel, Switzerland.
Subjects
Anti-lung cancer
Cisplatin
Ganoderma lucidum
Polysaccharides
Synergistic effect
SDGs
Publisher
MDPI
Type
journal article